Accumulating clinical evidence strongly supports PIK3CA mutation as a promising predictive biomarker for aspirin efficacy 9,10,11,12,13
Chapters: 00:00 Meet Joe Brown & His Journey 04:25 Leaving the Traditional Career Path 10:00 From Overweight to Fit 15:50 Business Success vs Health 19:20 Discipline Creates Results 25:00 Why People Are Finally Waking Up 29:30 Joe's Carnivore Journey 33:50 Discovering Peptides 38:30 TRT, Hormones & Optimization 47:20 Joe's Current Protocols 54:25 Health, Business & Personal Responsibility 59:00 Final Takeaways We cover: Joe's background Former stockbroker turned independent investor and financial educator YouTube channel: Heresy Financial explains the economy, markets, and how money actually works 5-year average annual return of 3940% vs market average of 1012% Runs a trade alert membership sharing his personal investments in real time The left turn finance & fitness parallels Left a high-paying career when he stopped believing in what he was selling same shift happening in health and Western medicine People don't change until the pain of staying the same exceeds the pain of changing Went carnivore January 1, 2021 lost 50 lbs in 5 months and never looked back Key mindset shift: trying to lose weight vs committing to an outcome Hashimoto's diagnosis the hidden roadblock Developed fatigue and afternoon crashes despite being in great shape and eating clean Diagnosed with Hashimoto's hypothyroidism likely aggravated by strict long-term carnivore (thyroid runs on carbs) Started naturally desiccated thyroid (NDT) felt normal almost immediately Thyroid medication spiked SHBG, binding up free testosterone despite total T of 800900 Now on 180mg TRT weekly total T over 2,000 but free T still low at 2025 due to SHBG of 56 Solution discussed: Proviron peels SHBG off androgen receptors, frees up testosterone naturally JD's current stack Testosterone propionate 180mg HCG 1,000 IU Mon/Wed/Fri HGH 2 IU (morning, fasted) Tesofensine clean energy, loves it in the morning IGF-1 LR3 pre-workout Thymosin Alpha-1 Wolverine Stack heavy use for shoulders and back Will's current stack (fertility prep) No testosterone (weaning down for fertility) HCG 1,500 IU Mon/Wed/Fri HMG 25 IU Mon/Wed/Fri Clomiphene 25mg daily Cabergoline 1mg/week (prolactin control + mood) BPC-157 + KPV daily Tesofensine helping offset low drive from pulling testosterone Real talk Blood work is your GPS you can't know where you're going without knowing where you are Tell your doctor everything find one who won't judge you Building a physique is hard
Oral supplementation (50150 g daily) may suit dietary deficiency without nerve involvement, but malabsorption cases require injections
Such drug-induced elevations compound the effects of systemic comorbidities, including hypertension, insulin resistance, and atherosclerosis, collectively impairing urate homeostasis through both enhanced production and reduced excretion
